Increasing evidence suggests that persistent Na+ current carried by Nav1.5 in cancer cells contributes to invasion and several studies have shown that other VGSC inhibitors reduce metastasis in preclinical models (Roger et al., 2003; Fraser et al., 2005; House et al., 2010; Yang et al., 2012; Driffort et al., 2014; Besson et al., 2015; Nelson et al., 2015a; Nelson et al., 2015b). The gene discussed is SCN5A; the disease is cancer.