For example, using a Vh of -80 mV, 300 μM ESL was shown to inhibit peak Na+ current by 50% in N1E-115 neuroblastoma cells expressing Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7 (Bonifacio et al., 2001). This evidence concerns the gene SCN2A and neuroblastoma.