In the murine neuroblastoma N1E-115 cell line, which expresses Nav1.1, Nav1.2, Nav1.3, Nav1.6, and Nav1.7, ESL and S-Lic both have a voltage-dependent inhibitory effect on the Na+ current (Bonifacio et al., 2001; Hebeisen et al., 2015). The gene discussed is SCN2A; the disease is neuroblastoma.