The EGF/EGFR is a critical signaling pathway in the pathogenesis of asthma, and both EGF and EGFR levels have been shown to be consistently increased in both human asthma and in animal models of asthma (Amishima et al., 1998; Puddicombe et al., 2000; Song L. et al., 2016). The gene discussed is EGF; the disease is asthma.