While much information has been gleaned from the PD mutations and the evolutionary precursors of the ROC:COR and ANK:ROC:COR domains from Dictyostelium and C. tepidium, respectively (Gilsbach et al., 2012; Deyaert et al., 2019; Wauters et al., 2019), high-resolution structural data for human LRRK2 has been largely missing. Here, LRRK2 is linked to Parkinson disease.