The Leucine-Rich Repeat Kinase 2 (LRRK2) is a large multi-domain kinase that is linked through numerous mutations to Parkinson’s disease (PD; Funayama et al., 2002; Paisán-Ruíz et al., 2004; Zimprich et al., 2004; Tan and Skipper, 2007) but is also implicated in Crohn’s disease (Hui et al., 2018). Here, LRRK2 is linked to Crohn disease.