Longitudinal analysis revealed age-dependent deterioration of functional networks in parallel with worsening tau pathology in the LC, and the appearance of plaques and tangles in forebrain regions (Cohen et al., 2013; Rorabaugh et al., 2017), a pattern similar to that observed in human AD patients (Balachandar et al., 2015; Badhwar et al., 2017). The gene discussed is MAPT; the disease is Alzheimer disease.