TARDBP and amyotrophic lateral sclerosis: α-synuclein inclusions, known as Lewy bodies, are found in PD and Lewy body dementias, while mutant huntingtin (mHTT) aggregates are formed in HD, and TAR DNA-binding protein 43 (TDP-43) aggregates are found in ALS and FTD brains (Nguyen et al., 2018).