IL1B and adult-onset Still disease: First-line treatment is usually based on nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, and corticosteroid-sparing drugs, mostly represented by conventional disease-modifying antirheumatic drugs (cDMARDs), as methotrexate and cyclosporine A. More recently, a beneficial role of IL-1 inhibitors in patients with AOSD or SOJIA has been described.