Because overexpression of cyclin D3 or mutation of D3 at Thr283 is frequently observed in Burkitt’s lymphoma and leukemia [6] and c-Myc driven murine lymphomas [21, 22] (Fig. S6), we further defined whether Fbxl8 has tumor suppressive function in hematopoietic cells. This evidence concerns the gene CCND3 and neoplasm.