Since a significant expression of IL-4 is observed in the COVID-19 group compared to H1N1 and CONTROL group (p = 0.003 and p = 0.05, borderline) and a lower expression of IL-13 and Sphingosine-1 in this group when compared with H1N1 (p = 0.007 and p = 0.05 respectively), it is suggested that IL-4 may be secreted not only by the Th2 pathway but before it. This evidence concerns the gene IL4 and COVID-19.