HMGB1 and colorectal carcinoma: According to levels of HMGB1 expression in the nucleus and cytoplasm, the 369 CRC patients were divided into four groups: nuclear HMGB1 expression was not strongly positive and cytoplasmic HMGB1 expression was negative in 22 patients; 254 exhibited strongly positive nuclear/cytoplasmic-negative HMGB1 expression; 37 were not strongly positive for nuclear HMGB1 expression and were cytoplasmic-positive; and 56 exhibited strongly positive nuclear/cytoplasmic-positive HMGB1 expression.