NK cells from LAG-3 deficient mice show defects in the killing of specific cancer cells.184 It is worth noting that blocking the LAG-3 pathway with the use of LAG-3 antibodies or even soluble LAG-3 does not have any effect on the cytotoxicity of human NK cells.176,185 Even so, targeting LAG-3 may be useful in immunotherapy due to its influence on T cell and NK cell effector function. Here, LAG3 is linked to cancer.