TIM-3 targeting effects do not affect non-tumor bearing tissues, although it does not seem to have any specificity.143 This remains one of the cancer research mysteries that although specificity remains a crucial factor in regulating immune responses in tissue.122,153,154 The upregulation of TIM-3 in several types of cancer raises concerns about the safety of all other tissues. The gene discussed is HAVCR2; the disease is cancer.