Subsequent blockade of TIGIT with monoclonal antibodies augment the antitumor and antiviral activity of NK cells and T cells based on studies on mouse models.96,97 The expression of TIGIT plays a vital role in suppressing activation and maturation of NK cells.92,98–100 Therefore, TIGIT has a role in tumor immunosurveillance, similar to the role of the PD-1/PD-L1 axis during tumor immunosuppression.44 The gene discussed is CD274; the disease is neoplasm.