CD274 and neoplasm: Furthermore, it has been established that anti-CD112R antagonists combined with anti-PD-L1 could also reduce tumor growth or metastasis.155,158,161,162 In an ex vivo study on human tumor-infiltrating lymphocytes, CD112R blockade enhanced T-cell function, and in combination with TIGIT or PD-1 blockade, further enhanced the effect.11,163 However, its function in human NK cells is still inadequately known.