Deletion of STAT3 significantly lowered spontaneous and caerulein-induced progression of PanIN to PDAC in GEMMs.87,88 Furthermore, lineage-tracing model showed that EMT precedes frank tumor progression in GEMMs, which is greatly accelerated by cerulean-induced inflammation.17 By inference, loss of STAT3 may retard inflammation- induced EMT, but this remains to be determined. This evidence concerns the gene STAT3 and neoplasm.