For example, inhibition of focal adhesion kinase (FAK) markedly reduces stromal collagen and also sensitizes PDAC cells to chemotherapy.108 Targeting the NF-κB pathway through suppressing Interleukin-1 receptor associated kinase 4 (IRAK4) sensitizes PDAC cells to genotoxic stress and simultaneously lowers the ability of CAFs to deposit collagen and foster tumor fibrosis, leading to improved response to chemotherapy.54,92,183. This evidence concerns the gene IRAK4 and neoplasm.