Constitutive activation of the NF-κB transcription factors is present in two third of PDAC and is tightly associated with tumor fibrosis, chemoresistance and poor prognosis in PDAC.92 One of the many important biological outputs from NF-κB activation is induction of inflammation, a hallmark of the PDAC TME and an important driving mechanism of EMT. Here, NFKB1 is linked to neoplasm.