ABL1 and leukemia: ABL1 (a.k.a. c-Abl) and ABL2 (a.k.a. Arg; Abl-related-Gene) non-receptor tyrosine kinases are best known for their oncogenic role in human leukemia, where they are partners in chromosomal translocations (e.g. BCR-ABL1, ETV6-ABL2) that activate the kinases and drive disease progression9.