Interestingly, in three publicly available CRC transcriptomic patient datasets (GSE39582/GSE103479/GSE14333)24–26, we found significantly higher levels of RALB gene expression in the poor prognostic CRIS-B subtype, compared to the levels observed in any of the other CRIS subgroups (Fig. 1E and Fig. S2A). This evidence concerns the gene RALB and colorectal carcinoma.