To understand the functions of ARHGEF11 upregulation in HCC progression, we silenced ARHGEF11 expression with two siRNAs (siARHGEF11-1 and siARHGEF11-2) in two highly metastatic hepatoma cell lines: HCCLM3 and SKHEP1. The gene discussed is ARHGEF11; the disease is hepatocellular carcinoma.