Furthermore, positive correlations between UPK1A-AS1 and CDK2, CDK4, CCNB1, and CCNB2, except for CCND1, were found in HCC samples (Supplementary Figure 4B), indicating that UPK1A-AS1 regulated CCND1 in a more complicated manner. This evidence concerns the gene CCNB2 and hepatocellular carcinoma.