GHRL and androgen insensitivity syndrome: In addition, expression of ghrelin receptor in the primary chondrocytes of AIS patients was significantly higher than that in common patients, and ghrelin could promote the AIS primary chondrocyte proliferation and upregulate the expression of cartilage-specific genes through extracellular regulated protein kinase (ERK)/signal transducer and activator of transcription (STAT3) pathways [15].