Through a literature review, we found that LHPP was reported as a tumor suppressor and negatively with pAKT (S473) in hepatocellular carcinoma (HCC) [26], and overexpression of LHPP downregulated pAKT to inhibit the proliferation and migration of cervical cancer [27], which is consistent with the phenotype induced by YTHDF2 and METTL3 in PCa. This evidence concerns the gene METTL3 and hepatocellular carcinoma.