Screening by m6A RNA immunoprecipitation (MeRIP) sequencing (MeRIP-seq), RNA immunoprecipitation (RIP) RT-qPCR and online database analysis in PCa suggested that LHPP and NKX3–1 were the direct targets of YTHDF2 and METTL3. The gene discussed is METTL3; the disease is posterior cortical atrophy.