METTL3 and posterior cortical atrophy: To investigate the regulatory relationship between YTHDF2 and LHPP, and the specific mechanisms of LHPP in PCa, we firstly detected their correlation in LinkedOmics online database, which suggested that LHPP was negatively correlated with both YTHDF2 (r = − 0.2078, P < 0.001) and METTL3 (r = − 0.2123, P < 0.001) (Fig. 6e).