METTL3 and posterior cortical atrophy: As the crucial m6A writer, METTL3 was also upregulated in TCGA PCa tissues (n = 498) compared to the normal controls (n = 52) (P < 0.001) (Fig. 1f) and in several cohorts from Oncomine (supplementary figure 1B-F), and there is an increasing tendency of METTL3 expression was associated with higher Gleason scores (Fig. 1g).