Considering that both LHPP and NKX3–1 can inhibit the AKT phosphorylation to restrain PCa progressions, we may suspect that YTHDF2 promotes the tumor progression via degrading LHPP and NKX3–1 to upregulate pAKT (S473 and T308). Here, NKX3-1 is linked to posterior cortical atrophy.