Screening by m6A RNA immunoprecipitation (MeRIP) sequencing (MeRIP-seq), RNA immunoprecipitation (RIP) RT-qPCR and online database analysis in PCa suggested that LHPP and NKX3–1 were the direct targets of YTHDF2 and METTL3. Here, LHPP is linked to posterior cortical atrophy.