Previous research on Alzheimer’s disease using rodent models found that decreases in hippocampal CBP activity levels are accompanied by decreased CREB activation, i.e., phospho-CREB levels at Ser-133, although overall CREB levels were not changed [34], emphasizing the need to understand the function of CBP in transcription and memory. This evidence concerns the gene CREBBP and early-onset autosomal dominant Alzheimer disease.