We found that in the mouse liver samples collected at 20 wks (with STZ+HFD induced tumor), the ITCH/miR-324-3p interaction shows negatively correlated expression between miRNA and gene (|Pearson correlation coefficient (PCC)|≥0.7) while RXRA/miR-423-3p, JUN/miR-342-3p, and AKT2/miR-423-3p show weak negative correlation. This evidence concerns the gene RXRA and neoplasm.