Many of the dysregulated miRNAs common in obesity and cancers were evidenced to regulate conditions such as insulin resistance, low-grade inflammation, cell proliferation and survival, dysfunction of adipose tissues, and increased oxidative stress through targeting VEGF, Ras, HIF1- α, PI3K/Akt, JAK/STAT3, MAPK, ERK/p38, and NF-k β [19, 21–25]. The gene discussed is STAT3; the disease is obesity due to melanocortin 4 receptor deficiency.