Between obesity and early-stage liver cancer, upper panel of Fig. 2, two interactions (miR-152/ECHS1 and miR-100/ALDH9A1) remained the same (in red) and another two common miRNAs (miR-193b and let-7b) regulate different gene targets in LIHC compared to obesity. Here, ALDH9A1 is linked to obesity due to melanocortin 4 receptor deficiency.