siRNA-mediated BCL2 silencing as well as TRAIL-dependent NK cells activation provoked massive cell death in cancer cells, while sparing healthy normal cells due to the expression of Bcl-xL, which counteracts RIG-I mediated apoptosis [54], or TRAIL-R3 and TRAIL-R4, which antagonise TRAIL-death signal [56]. The gene discussed is TNFSF10; the disease is cancer.