The peptide which disrupts the interaction between GluN2B and PSD-95/nNOS uncoupled NO production by nNOS from NMDAR-mediated excitotoxicity in cultured neurons [30] and in Alzheimer’s disease mouse models [31] and has been assessed in human ischemic stroke patients [32,33]. The gene discussed is NOS1; the disease is early-onset autosomal dominant Alzheimer disease.