Adiposity and adipose tissue dysfunction, associated with insulin resistance, lead to the release of proinflammatory cytokines and free fatty acids (FA) in the circulation, as well as changes in the production of adipokines (leptin and adiponectin), which likely contribute to the pathogenesis of obesity and diabetes-induced kidney disease [12,14,15]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.