The report by Broggi et al. [44] used K14-VEGFR-3-Ig transgenic mice lacking dermal lymphatics, to show that lymphatics were a major route of EV trafficking from the interstitial space into the lymph fluid, lymph nodes (LNs), and systemic circulation, and that this could be a source of tumour-derived EVs. This evidence concerns the gene FLT4 and neoplasm.