It is possible that ZIKV, similar to HCV, interferes with sMafs to impair the induction of ARE-dependent genes, since major Nrf2 target genes including HO-1, NQO1, GCL, GST were not dysregulated upon ZIKV infection despite the induction of oxidative stress; however, further studies are needed to assess this [76,77,78]. This evidence concerns the gene HMOX1 and Zika virus infectious disease.