Our analysis revealed that miR-205-5p, which was downregulated at the intracellular level, could potentially target the gene ATF3 (activating transcription factor 3), besides ASNS. Furthermore, we found multiple EV-associated miRNAs with decreased levels upon infection with ZIKV Polynesia, which potentially regulate the same mRNA targets implicated in oxidative stress or ER stress (Table 7). The gene discussed is ASNS; the disease is infection.