ATF3 and infection: Our analysis revealed that miR-205-5p, which was downregulated at the intracellular level, could potentially target the gene ATF3 (activating transcription factor 3), besides ASNS. Furthermore, we found multiple EV-associated miRNAs with decreased levels upon infection with ZIKV Polynesia, which potentially regulate the same mRNA targets implicated in oxidative stress or ER stress (Table 7).