The RD prevented the development of osteomalacia in other VDR knockout mice [19], and, moreover, no signs of osteomalacia were observed previously in our RD-fed VDRΔ/Δ mice at the baseline [9], which was confirmed in the current study by the absence of enhanced amounts of unmineralized bone matrix, as visualized by inverted qBEI imaging. This evidence concerns the gene VDR and osteomalacia.