TP53 and neoplasm: Yan et al. (2015) [238] demonstrated that CAP increased the percentage of apoptotic tumour cells by blocking the cell cycle at the G2/M checkpoint, and this effect was mediated by reduced intercellular cyclin B1 and cyclin-depend kinase1, increased p53 and cyclin depending on kinase inhibitor and an increased Bcl-2-like protein4 (BAX)/B cell lymphoma2 (Bcl-2) ratio.