Loss of viability, higher numbers of cell cycle arrests, and the increased activity of caspase 3 connected with a higher apoptosis rate after CAP treatment were observed in several cell lines, including HeLa, squamous carcinoma YD-9 cell lines and melanoma G361 cell lines, however, these changes were more significant in p53 mutated cell lines compared to wild type p53 cells [233]. Here, TP53 is linked to squamous cell carcinoma.