CHM4B’s presence in Reactome is mostly associated with antigen processing, HIF viral life cycle, and autophagy, some of which are shared among both variants while others differ (Table S5), e.g., late endosomal microautophagy pathways also include hemoglobin subunit beta HBB (P68871) (AAE6 and EPE6), as well as HIV infection pathways, which also include E3 ubiquitin-protein ligase RBX1 (P62877), tyrosine-protein kinase HCK (P08631) (AAE6), cyclin-dependent kinase 9 CDK9 (P50750), and F-box/WD repeat-containing protein 1A FBW1A (Q9Y297) (EPE6). This evidence concerns the gene HBB and HIV infectious disease.