In the latter, it is mostly inactive and controlled by kinases, such as glycogen synthase kinase 3 (GSK3), casein kinase 1 (CK1), axin, and adenomatous polyposis coli (APC), a tumour suppressor gene often mutated in colon cancer ([99] and references therein). The gene discussed is AXIN1; the disease is malignant colon neoplasm.