Stowe et al. (2012) [73] reported an interaction between neurofibromin and Spred1 (Sprouty-Related EVH1 domain-containing protein), a protein that has been shown to negatively regulate Ras/MAPK signaling and mutations of which cause Legius syndrome, a RASopathy that shares mild phenotypes with NF1 [74]. The gene discussed is NF1; the disease is Legius syndrome.