In this work, the authors examined tau filaments isolated from three CTE patients and found that approximately 90% of the tau filaments, denoted as Type I, coming from these cases are structurally different from the paired helical filaments (PHFs) and straight filaments (SFs) found in AD and filaments in other tauopathies such as Pick’s disease [47,57,58]. The gene discussed is MAPT; the disease is tauopathy.