With respect to the tau pathology in CTE compared to that in AD, for instance, the perivascular distribution of NFTs in CTE is found to affect both neurons and astrocytes concentrated preferentially at the superficial layers of the cortical sulci (layer II and III), which is strikingly different from the NFTs in AD which affect neurons predominant at the deep cortical layers, with a higher density in layer V and VI [264,408]. The gene discussed is MAPT; the disease is Alzheimer disease.