In this regard, in prostate cancer cells, genotoxic stress has been shown to induce non-random chromosomal translocations mediated by upregulation of LINE-1-encoded ORF2 protein and AID [77], highlighting the importance of transposons and AID/APOBECs as agents of genome remodelling and cancer development in stressful environmental conditions. This evidence concerns the gene AICDA and Familial prostate cancer.