Furthermore, the crosstalk between VEGF and Notch pathways has been established to promote EndMT in endothelial cells of tumors [116], while the addition of VEGF was shown to induce EMT in A549 lung cancer cells [117] and elicit the appearance of EMT markers in pre-invasive prostate cancer cells [118]. The gene discussed is VEGFA; the disease is Familial prostate cancer.