Nonetheless, solid conclusions on the role of the VEGF/VEGFR pathway in promoting autocrine stimulation of tumor cell migration and invasion, are difficult to be drawn, and are perhaps cell- and context-dependent, since contrary to the above, VEGF was demonstrated to negatively regulate tumor cell invasion and mesenchymal cell transition through a MET/VEGFR2 complex in glioblastoma mouse models [120]. This evidence concerns the gene VEGFA and glioblastoma.