MAPK3 and colorectal cancer: Furthermore, RNAi-mediated depletion of VEGF decreased cell survival and enhanced sensitivity to chemotherapy of colorectal cancer cells (i.e., HCT116, SW480, HT29, HCP-1) by disrupting AKT and ERK1/2 signaling; notably, ribonucleic acid interference (RNAi)-mediated depletion of VEGFR1 replicated the effects of VEGF depletion on phospho-AKT and phospho-ERK1/2 levels [65].