VEGFR2 phosphorylation in several breast cancer cell lines (i.e., MDA-MB-468, T47 d, MCF-7, HBL-100 and in a primary breast cancer culture) was enhanced by VEGF-A stimulation leading to activation of ERK1/2 and Akt pathways, indicating that the VEGFR/VEGF-A pathway might play crucial role in the regulation of survival and proliferation of breast cancer cells [78]. The gene discussed is VEGFA; the disease is breast carcinoma.