Extravasation into the tumor tissue is dependent upon interactions with adhesion molecules expressed on the immune cells themselves and the luminal surface of the tumors’ endothelial lining such as E-cadherin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) [13,15,121]. Here, ICAM1 is linked to neoplasm.