Specifically, expression of VEGFR1 has been reported in a panel of breast cancer cell lines (i.e., DU4475, MCF-7, T-47 D, SK-BR-3, MDA-MB-157, MDA-MB-175, MDA-MB-231, MDA-MB-435, MDA-MB-468, AU565, BT-474, BT-483, HCC38, UACC-812, ZR-75–1), followed by the observation that tumor cell growth is supported by selective VEGFR1 signaling and it is mediated by downstream activation of MAPK/ERK and PI3K/Akt pathways [99]. This evidence concerns the gene AKT1 and breast carcinoma.