Moreover, in a series of 142 invasive breast carcinomas, 64.5% of them tested positive for VEGFR2 expression and were also associated with the expression of Ki67 and topoisomerase-IIa proliferation indexes suggesting that VEGF may act as a growth factor via VEGFR2 in these cancer cells [102]. The gene discussed is KDR; the disease is invasive breast carcinoma.