The first TF-targeting photosensitizer conjugate was generated by conjugating active-site mutated fVII (K341A) protein to the photosensitizer verteporfin for the PDT treatment of breast cancer in a mouse model [88] and choroidal neovascularization in a rat model [105], the latter is a cause of age-related macular degeneration in humans. The gene discussed is TF; the disease is breast carcinoma.