NFE2L2 and cancer: In our previous studies on noni juice, we identified alkyl catechols (4-methyl catechol, 4-ethyl catechol, and 4-vinyl catechol) [12] and scopoletin [13], among which 4-methyl catechol, 4-ethyl catechol, and 4-vinyl catechol are potent molecules that provide protection against diseases, like cancer associated with oxidative stress, by stimulating nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factors.