A previous study reported that S1P can activate cell migration in S1P1-overexpressing B16F10 cells and, inversely, inhibit melanoma cell migration in S1P2-expressing cells, with the concomitant inhibition of the small GTPase Rac and stimulation of RhoA, demonstrating a receptor subtype-specific action of S1P in these cells [92]. This evidence concerns the gene AKT1 and melanoma.