Therefore, a great deal of effort is being made to identify predictive biomarkers including evaluation of PD-L1 expression, tumor infiltrating lymphocytes, tumor mutational burden, microsatellite instability, mismatch-repair deficiency, neoantigen load, gene expression signatures, T-cell receptor diversity, and clonality, circulating immune-cell subsets, serum protein signatures, soluble PD-L1, gut microbiome, human leukocyte antigen genotype, and germline single-nucleotide polymorphism [4]. Here, CD274 is linked to neoplasm.