MYC and colorectal carcinoma: Indeed, in human CRC, most of the essential factors involved in ribosome biogenesis are overexpressed due to highMYC expression levels, as exemplified by the MYC-target gene, aryl hydrocarbon receptor, which is co-upregulated with MYC in CRC and promotes HCT-116 CRC cell proliferation by activation of a ribosome biogenesis transcriptional signature [90].