Although it is well documented that ribosome biogenesis can be controlled by growth factor receptors through MAPK/RAS/signaling [52,91] and that constitutive activation of KRAS represents a major determinant of some CRC subtypes, only few studies have explored the contribution of the oncogenic RAS pathway in ribosome biogenesis-mediated colorectal tumorigenesis. The gene discussed is KRAS; the disease is colorectal carcinoma.