CX-3543 induced in vitro apoptosis of various human CRC cell lines, including p53 mutant COLO-205, HCC-2998, HCT-15, and KM12 cells, and p53-wild-type HCT-116 cells, and inhibited in vivo HCT-116 tumor xenograft growth [185,186]. Here, TP53 is linked to colorectal carcinoma.