Our laboratory was the first to report the contribution of CD38, a type II transmembrane glycoprotein, to the regulation of intracellular calcium in airway smooth muscle (ASM) and airway hyperresponsiveness (AHR) in a series of studies employing cellular imaging, molecular and biochemical techniques in cells, tissues and animal models (e.g., [5]). The gene discussed is CD38; the disease is airway hyperresponsiveness.