Our previous work delineated the role for the cyclase activity of CD38 whereby its product cADPR mediates calcium hyperresponsiveness of human ASM treated with asthma-relevant cytokines [7,8,9,10], and established the contribution of CD38 to airway hyperreactivity to contractile agonists in cytokine and mouse models of allergic airway disease [12,13,14]. Here, CD38 is linked to asthma.