DMTF1 and neoplasm: Previous publication from WFU with samples of 51 NSCLC [39] showed that LOH of the hDMP1 gene was found in 33.3% of samples with 5′ primer, 36.1% with 3′ primer (average 35%), but signs of biallelic involvement (promoter hypermethylation or complete loss) was extremely rare (the former 2.2% and 0% for the latter) in human lung cancer indicating that hDMP1 was haploinsufficient for tumor suppression [35,51].