TP53 and neoplasm: We also conducted survival analysis of hDMP1; p53 double LOH cases (n = 10 in UM samples) although the analysis was difficult due to mutual exclusiveness of LOH for hDMP1 and p53. We expected that when inactivation of two tumor suppressors overlap, the prognosis of patients will be even worse than p53 LOH alone; however, the negative effect of p53 loss was strikingly improved by simultaneous loss of hDMP1 (Figure 2).