Itahana et al. studied the role of ARF in apoptosis and found that the mitochondrial protein p32/C1QBP bound to the ARF C-terminus, where p32 is required for ARF to localize to mitochondria to induce apoptosis, demonstrating the essential role of ARF in tumor suppression and programmed cell death [27]. The gene discussed is CDKN2A; the disease is neoplasm.