Activating mutations in the NOTCH1 pathway, including mutations in NOTCH1 and/or FBXW7 (which encodes for a ubiquitin ligase involved in the degradation of active intracellular NOTCH1 (ICN1)), are found in approximately 60% of T-ALL patients [34,35]. The gene discussed is FBXW7; the disease is acute lymphoblastic leukemia.