FUSION has been used to screen for functional similarity between proteins using 14,355 unique siRNA pools, 344 microRNA mimics, and approximately 1200 natural products fractions in a K-Ras mutant colon cancer cell line and was used to identify novel proteins required for modulation of autophagy and proteins functionally similar to Kinase suppressor of Ras 1 (KSR1) and to determine the target and mechanism of action (MoA) of uncharacterized naturally occurring small molecules [12,13,14,15,16,17,18,19,20]. This evidence concerns the gene KSR1 and colonic neoplasm.