CASC2 and central nervous system cancer: Here we show significant CASC2 expression loss and drastic rise of miR-21 expression in glioblastomas as compared to the average expression levels in lower grade (II–III) gliomas (p = 0.0003 and p < 0.0001, respectively) and control non-cancerous brain tissues (p = 0.005 and p < 0.0001, respectively) (Figure 1A,B).