IDH1 and glioma: When all samples were divided into IDH1 gene mutated (IDH1mut, n = 18) and IDH1 wild-type (IDH1wt, n = 78) gliomas, we observed a tendency of lower expression of CASC2 in IDH1wt (p = 0.053) and highly significant relationship between higher miR-21 expression and IDH1wt gliomas (p < 0.0001) (Figure 2A,B).