Various lncRNAs, including homeobox (HOX) transcript antisense RNA (HOTAIR), metastasis associated lung adenocarcinoma transcript (MALAT), colorectal neoplasia differentially expressed (CRNDE), have been identified as novel players in glioma pathogenesis demonstrating associations with tumor subtype, histological stage, tumor isocitrate dehydrogenase (IDH) mutational status, chemosensitivity, and patient survival [4,5,6,7,8]. This evidence concerns the gene IDH1 and central nervous system cancer.