CASC2 and central nervous system cancer: The combined effect of low CASC2 and high miR-21 expression (n = 30) in glioma was shown to be associated with significantly decreased overall survival compared to patients with the combination of high CASC2 and low miR-21 expression (n = 26) in tumor tissue (Log-rank test, χ2 = 12.91, df = 1, p = 0.0003; Figure 4C).