VPS35 and Parkinson disease: Initially, Vilarino-Guell and coworkers identified an aspartic-acid-to-asparagine mutation at residue 620 (p.D620N, c.1858G>A) in a Swiss family, three other families, and one patient with sporadic PD, while a proline-to-serine variant was identified at residue 316 (p.P316S, c.946C>T) in the VPS35 gene in a United States family in 2011 [6].