Subsequently, gene ontology (GO) and gene set enrichment analysis (GSEA) associated SLIT2high APL patients with the terms “PML nuclear body formation”, “autophagosome organization”, and “mitotic G2/M arrest”, while low SLIT2 APL patients were associated with “regulation of transcription by RNA pol II”, “cell cycle progression”, and “DNA replication” (Figure 1F,G). This evidence concerns the gene PML and acute promyelocytic leukemia.