SLIT2 and acute promyelocytic leukemia: Furthermore, the best-fitted multivariate Cox proportional hazards model for OS, including age (continuous variable), leukocyte counts (continuous variable), and SLIT2 transcript levels (continuous variable), indicated that high SLIT2 transcript levels were independently associated with increased OS in the IC-APL cohort (hazard ratio, HR: 0.94, 95% CI: 0.92–0.97; p < 0.001) (Figure 1C).