Interestingly, we found that APL patients with high SLIT2 expression were associated with cell cycle controllers (CDKN1A, TP53, and TP73), whereas patients with low SLIT2 expression were linked to cell proliferation genes (AKT1, MYB, MIK67, and MAP3K11) and poor APL/AML prognosis marker (FOXM1, AREG, and PIM1). This evidence concerns the gene AREG and acute promyelocytic leukemia.