Empty sella is one of the causes of hypopituitarism, and refers to an intrasellar herniation of the subarachnoid space through a congenital defect in the diaphragm sellae or pituitary involution.[1] Central diabetes insipidus may be masked by adrenal insufficiency and uncovered by subsequent steroid therapy, due to involvement of arginine vasopressin (AVP)-dependent and AVP-independent mechanisms.[2] Here, we report a rare case of a patient with empty sella who developed central diabetes insipidus following glucocorticoid (GC) administration. The gene discussed is AVP; the disease is hypopituitarism.