F8 and rheumatic disorder: In autoimmune or rheumatic diseases, when patients present with spontaneous hemorrhage and delayed bleeding combined with prolonged APTT, AHA should be suspected and a complete laboratory assessment is critical, including detection of coagulation, FVIII, and FVIII inhibitors.[29] Once AHA is diagnosed and treated urgently, immunosuppressive therapy is important in addition to supplementation and recovery of hemostasis.