And osteopenia in F508del-Cftr mice provides the KRT8-F508del-CFTR reaction to reform the abnormal bone structure in cystic fibrosis.[19] In addition, the potential proteins associated with VO disease showing elevated autoantibody responses were reviewed based on literature and a data mining approach using Open Targets Platform (https://www.targetvalidation.org/)[14] as well as UniProt Platform (https://www.uniprot.org/).[15] The results are shown in Supplemental Digital Content (Appendix 8, which lists the disease associations of biomarkers identified across 4 subjects. The gene discussed is CFTR; the disease is Osteopenia.