Patients with SARS-CoV-2 are also experiencing severe inflammatory responses with marked cytokine storm which may induce liver inflammation and induce vascular thrombosis.[6] Current literature supports the hypothesis that patients with higher transaminase levels on presentation, particularly in the hepatocellular pattern, have a higher likelihood of developing severe disease.[6] This patient was diagnosed with a SLE flare during the hospital course by low C3, C4, and elevated dsDNA levels. Here, C4A is linked to systemic lupus erythematosus.