Venlafaxine can decrease TNF-alpha, IL-1beta or decrease the activity of inflammatory cells in cyclophosphamide-induced acute lung injury.[16] Curcumin has been shown to downregulate IL-17a and mediate the p53-fibrinolytic system in order to alleviate acute lung injuries due to bleomycin.[17] The efficacy of immunomodulation medication in association with chemotherapeutic agents requires further research for clarification. Here, TNF is linked to injury.