Impaired HRQOL has been reported for patients with PBC in many studies.[19–21] We also showed that HRQOL was impaired and lower serum albumin level was independently associated with fatigue scores from the short-form 36 questionnaire among Japanese PBC patients.[22] Although patients with AIH and PBC both showed impaired HRQOL, few reports have provided direct comparisons. The gene discussed is ALB; the disease is primary biliary cholangitis.