Immunohistochemical staining revealed that tumor cells neuron-specific enolase (NSE) (+++), chromogranin A (CgA) (+++), synaptophysin (Syn) (-),estrogen receptor (ER) 90% medium intensity (+), progesterone receptor (PR) 60% medium intensity (+), human epidermal growth factor receptor-2 (HER-2) (1+) and antigen KI-67 index of 50%. Here, ESR1 is linked to neoplasm.